New-variant Creutzfeldt–Jakob disease and scrapie are typically initiated by extracerebral exposure to the causative agent, and exhibit early prion replication in lymphoid organs1,2. In mouse ...

The cofactor preferences for in vitro propagation of the protease-resistant isoforms of the prion protein (PrPSc) from various rodent species were investigated using the serial protein misfolding ...

The detection to α-synuclein (αS) assemblies as a biomarker of synucleinopathies is an important challenge for further development of an early diagnosis tool. Here, we present proof of concept ...

MOLECULAR BIOLOGY OF PRIONS Nature of the infectious agent. A number of converging lines of experimental evidence now firmly support the idea that prions consist principally, or entirely, of abnormal ...