PRPS1 loss increases sensitivity to oxidative stress, while PRPS2 loss induces reductive stress. Targeting PRPS disrupts redox balance, offering a potential strategy for novel lymphoma therapies.

Eliminating PRPS1’s function enhanced sensitivity to oxidative stressors and damage within cells, while eliminating PRPS2’s function triggered reductive stress. Essentially, the team found that MYC ...

A study led by researchers at the University of Cincinnati Cancer Center provides new insights into how a key oncogene contributes to the development and progression of lymphoma, potentially informing ...

A study led by the University of Cincinnati Cancer Center reveals how the MYC oncogene accelerates lymphoma growth through the PRPS enzyme, prompting potential targeted treatments.

MicroRNA-124 reduces the pentose phosphate pathway and proliferation by targeting PRPS1 and RPIA mRNAs in human colorectal cancer cells. Gastroenterology 149, 1587.e11–1598.e11. doi: ...

DNA sequencing is used to read the nucleotide sequence in all or part of an organism’s genetic material. The method «next-generation sequencing» (NGS) has revolutionised the speed and capacity of DNA ...