CAR-T cells, which are genetically programmed to specifically recognize and kill target cells, have altered the therapeutic ...

The study reviews CAR-T cell advancements in lymphoma treatment, addressing T cell exhaustion and tumor immune evasion with ...

Another study compared the health status of 12 men, aged between 37 and 55, after they practised forest bathing in three different forests. Afterwards, the men showed a 50 per cent increase in natural ...

Background: PRF1 gene mutations are associated with familial haemophagocytic lymphohistiocytosis type 2 (FHL2). Genotype–phenotype analysis, previously hampered by limited numbers of patients, was for ...

Classic CAR-T strategies genetically modified CD4/CD8 T cells for expressing CD19 and target healthy and autoreactive B cells, thus releasing perforin and granzyme to induce cell death. CAAR-T cells ...

Additionally, expression levels of CD107a/LAMP1, Granzyme B, Perforin, and IFN-γ were markedly upregulated in CD8 + T cells from GCB-LMP1/2A mice than in controls . These results indicate that CD8 + T ...

Antiretroviral therapy (ART) initiated in the acute phase of HIV infection (AHI) results in a smaller viral reservoir. However, the impact of early HIV-specific T-cell responses on long-term reservoir ...

Ma LL, Wang CL, Neely GG, Epelman S, Krensky AM, and Mody CH NK cells use perforin rather than granulysin for anticryptococcal activity J Immunol 2004 173 3357-3365. Crossref. PubMed. CAS. Google ...

The inflammasomes are crucial innate immune signaling platforms implicated in immune defense against infections and autoimmune/autoinflammatory disorders such as multiple sclerosis and Alzheimer’s ...