Glucose-6-phosphate dehydrogenase (G6PD) is the only rate-limiting enzyme in the pentose phosphate pathway (PPP). Rapidly proliferating cells require metabolites from PPP to synthesize ribonucleotides ...

Loopmans et al. show that the pentose phosphate pathway in chondrocytes provides reducing power to ensure proteostasis necessary for bone lengthening.

Enrichment analysis revealed that Ang-II induced HTN causes significant metabolic shift in the brain by altering the pathways which are involved in glycolysis/gluconeogenesis (false discovery rate ...

PFKL also acts as a negative regulator of reactive oxygen species bursts in phagocytes, and its knockdown leads to an increase in glucose flux into the pentose phosphate pathway, which promotes NADPH ...

Anna Hirsch has now taken a closer look at a less obvious difference between bacteria and humans that has not yet been pharmaceutically exploited: the so-called methylerythritol phosphate pathway ...