LTI-03 reduced the expression of profibrotic proteins in IPF PCLS, including Col-1α1 and platelet-derived growth factor receptor beta (PDGFRB). Unlike nintedanib, LTI-03 did not induce cellular ...

In vascular smooth muscle cells, uPAR interacts with the platelet-derived growth factor receptor-β (PDGFRB), promoting PDGF-independent signalling 121. Several studies, discussed below ...

Here they show that heterodimerization of the receptor tyrosine kinases PDGFRa and PDGFRb negatively affects downstream ERK1/2 signaling and cellular proliferation, due in part to rapid ...

Presentations further support the dual mechanism of LTI-03 and the development of Cav1-related peptides for the treatment of idiopathic pulmonary fibrosis (IPF) Company recently initiated RENEW ...

Endocardial cells are specialized endothelial cells that form the innermost layer of the heart wall. By virtue of genetic lineage–tracing technology, many of the unexpected roles of endocardium during ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. CD206+ macrophages promote skin wound healing ...

The heart is lined by a single layer of mesothelial cells called the epicardium that provides important cellular contributions for embryonic heart formation. The epicardium harbors a population of ...

Department of Oncology, Clinical and Basic Research Team of TCM Prevention and Treatment of NSCLC, The Second Clinical College of Guangzhou University of Chinese Medicine, Guangdong Provincial ...

This important study demonstrates the therapeutic potential of recombinant human PDGF-AB/BB proteins in reducing the senescent signatures of primary human intervertebral disc cells. The study ...

Introduction: Alzheimer’s disease (AD) is the most common cause of dementia in the elderly. However, the particular cause of AD development has not been fully elucidated. Currently, cellular ...