Mutations in the PS1 gene are responsible for the most aggressive form of AD and account for 18-50% of all early-onset AD cases. [4] PS1 mutations are mainly missense substitutions that are ...
Inherited variants in the APP, PS1, PS2, and APOE genes all cause A-beta accumulation in the brain. Mutations in the PS1 gene are responsible for the most aggressive form of AD and account for 18 ...
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