LOS ANGELES — The novel norepinephrine, dopamine, and serotonin reuptake inhibitor (NDSRI) centanafadine (Otsuka Pharmaceutical Co., Ltd.) is effective and “clinically meaningful” for adult ...

We previously used the MEKi PD0325901 to identify a set of 52 genes that comprises the transcriptional output of the ERK pathway in BRAF V600E tumors. To investigate whether non-MEK substrates of BRAF ...

Future work will be required to dissect this temporal regulation and fully elucidate the interplay between Sgo1-PP2A, ATRX, and Wapl in the protection of centromeric cohesion. We noticed that, in ...

(L–N) Total PP2A, the demethylated PP2A at Leu309 (deML309-PP2A), and the phosphorylated PP2A at tyrosine-307 (pY307-PP2A), total ERK, and pERK in cell lysates, and the level of PP1 catalytic subunit ...

Georgia Southern University has introduced its 2025–26 Erk Russell Fund (ERF) membership license plate, paying tribute to the school's longtime mascot, “Freedom,” and recognizing his enduring impact ...

Integrated single-cell RNA-seq analysis identifies ferroptosis-driven tumor microenvironment features, enabling a prognostic risk model and therapeutic targets to advance precision medicine for triple ...

Ochratoxin A (OTA) is a mycotoxin which could cause strong immunosuppressive toxicological effects in animals and humans. Heterophil extracellular traps (HETs) as a novel defense of chicken ...

Enantioselective oxygenation of unactivated C(sp3)–H bonds via asymmetric metalation remains an unsolved challenge. Herein we report the development of a Pd-catalyzed, enantioselective C(sp3)–H ...