PME-1 is a protein that modifies other proteins by removing methyl groups, but high levels of PME-1 are observed in some diseases, including Alzheimer's disease (AD) and cancer. In the study, "Two ...

In a recent study published in The FASEB Journal, researchers found that PME-1 can affect cell signaling downstream of the tumor suppressor complex PP2A in two distinct ways: by removing ...

Here the authors report that RNA-binding protein LIN28B and its target HMGA2 drive basal PDAC pathogenesis by reducing PP2A methylation and activity, resulting in enhanced protein synthesis and ...

Here, using tandem affinity purification, we identified protein phosphatase 2A (PP2A) as a BZR1-interacting protein. Genetic analyses demonstrated a positive role for PP2A in brassinosteroid ...

Here, we demonstrate that Protein Phosphatase 2A (PP2A) regulatory subunit B'kappa constrains SIT1 activity under salt stress. B'kappa-PP2A deactivates SIT1 directly by dephosphorylating the kinase at ...

Our data further suggest that ATRX may become particularly important for maintaining centromeric cohesion during metaphase, after the Sgo1-PP2A complex redistributes toward kinetochore-proximal ...

This research was supported by the National Natural Science Foundation of China (Grant Nos. 82472687, 82073132, 82122054, and 82203340), the CAMS Innovation Fund for Medical Sciences (Grant No.

The authors note that Figs. 1, 3, and 4 appeared incorrectly in the published article due to errors made during figure preparation. In Fig. 4A the representative image of CREB in the nuclear fraction ...

Objective: A bibliometric approach was employed to systematically analyze the trends and potential future developments in lactic acid-related cancer research over the past 10 years. Method: We ...

This study presents a useful finding for the ferroptosis-mediated tumor microenvironment (TME) in triple-negative breast cancer (TNBC) using public single-cell RNA sequencing (scRNA-seq) and bulk RNA ...