Takeda has bolstered its neuroscience pipeline by licensing drug candidates from California biotech AcuraStem targeting PIKfyve, which is gathering attention as a drug target in amyotrophic ...

The small-molecule PIKfyve inhibitor – called VRG50635 – has been administered to the first subject in the phase 1 trial involving healthy volunteers, according to the San Francisco-based ...

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Joint Research Laboratory of Advanced Functional Materials Science, Osaka University Graduate School of Dentistry, Suita 565-0871, Japan Department of Dental Biomaterials, Osaka University Graduate ...

Chair of Neuroanatomy, Institute of Anatomy, Faculty of Medicine, Ludwig-Maximilians University of Munich (LMU), Munich, Germany Center for Molecular Biology of Heidelberg University (ZMBH) and German ...

In the last decades, important progress has been achieved in the understanding of the neurotrophic effects of intermittent fasting (IF), calorie restriction (CR) and exercise. Improved neuroprotection ...

When PIKfyve is inhibited and the lysosomal recycling of lipids switches off, tumor cells can activate this pathway to generate their own fatty acid molecules for energy. Additional experiments in the ...

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