The p53 protein is a transcription factor that acts as a tumour suppressor by causing growth arrest or apoptosis in response to DNA damage and other forms of cellular stress 1. The activity of p53 ...

FSHD is a rare genetic disease characterized by muscle weakness and wasting due to the activation of the DUX4 gene, affecting thousands of individuals without approved treatments. DYNE-302 targets ...

These findings suggest that preexisting and severe skeletal muscle disease in FSHD has the potential to be reversed by targeting the DUX4 mRNA with DYNE-302. FSHD is a rare, progressive, genetic ...

These findings suggest that preexisting and severe skeletal muscle disease in FSHD has the potential to be reversed by targeting the DUX4 mRNA with DYNE-302. FSHD is a rare, progressive ...

Fulcrum had identified inhibitors of p38/ mitogen activated protein kinase (MAPK) as powerful inhibitors of DUX4 expression. DUX4 is the gene that is the root cause of FSHD, a progressive muscle ...

The new drug candidate for FSHD will combine an RNA molecule from miRecule targeting double homeobox 4 (DUX4) – a protein that is mutated in FSHD – with a nanobody developed by Sanofi that ...

These data as well as research supporting KHDC1L as a novel DUX4 regulated circulating biomark Avidity Biosciences, Inc. (Nasdaq: RNA), a biopharmaceutical company committed to delivering a new ...

Saint Louis University's IDBI Summer Program in Undergraduate Research (IDBI-SPUR) provides paid summer research opportunities and structured training activities for SLU undergraduate students working ...

This fundamental study identified a novel role of NOLC1 in regulating p53 nuclear transcriptional activity and p53-mediated ferroptosis in gastric cancer. After major revisions, the evidence ...

Domain organization of p53 isoforms. Overview of the so far described p53 isoforms that are formed by a combination of four N-terminal (TAp53, Δ40p53, Δ133p53 and Δ160p53) and three C-terminal ...

During aging, deterioration in cardiac structure and function leads to increased susceptibility to heart failure. The need for interventions to combat this age-related cardiac decline is becoming ...