Tumor MYCN status, ploidy, SCA status (1p and 11q), and International Neuroblastoma Pathology Classification histology were determined centrally. Survival analyses were performed for combinations of ...

The tumour also contained extra copies of the gene for a protein that is a notorious driver of childhood cancers, the transcription factor MYCN. MYCN turns genes on to make cells replicate during ...

At two years of age, Harlyn Hurford should be running around the park and playing with his much-loved dinosaurs, but instead ...

Harlyn carries the MYCN gene, which is linked to more aggressive tumour growth and a poorer prognosis. He has been given a one in two chance of survival. Mum Ebony Hurford cuddles her son Harlyn ...

Only the later tumor cells carry the already known duplications or alterations of the cancer genes MYC, MYCN or PRDM6 that are typical for these types of medulloblastoma. "We therefore assume that ...

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Effect of extrachromosomal DNA (ecDNA) on MYCN amplified neuroblastoma and patient outcomes. This is an ASCO Meeting Abstract from the 2025 ASCO Annual Meeting I. This abstract does not include a full ...

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