Results In response to chronic stimulation by Ang II, there were significant increases in myocardial expression of MMP2, MMP9 and MT1-MMP in both WT and ACE2KO mice with elevated plasma Ang II levels.

A cationized pullulan hydrogel was thus prepared to cover bare metal stents that could be further loaded with small interfering RNA (siRNA) targeted at MMP2 for gene silencing in vascular cells. The ...

Background: Triple-negative breast cancer (TNBC), the most lethal breast cancer subtype, demonstrates poor prognosis due to its high rates of metastasis, recurrence, and mortality. The metastatic ...

Aortic dissection (AD) is the separation of medial layers of the aorta and is a major cause of death in patients with connective tissue disorders such as Marfan syndrome. However, molecular triggers ...

This important study uses single-cell transcriptomics to analyze syncytiotrophoblasts in two trophoblast organoid models compared to primary placental tissue, providing compelling insights into ...

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This is valuable work with theoretical implications for possible mediation by MMP12 in the link between atherosclerosis and intracranial aneurysms, using Mendelian Randomization for causal inference.

Correspondence to Professor Shiquan Sun, Xi'an Jiaotong University, Xi'an, Shaanxi, China; sqsunsph{at}xjtu.edu.cn; Professor Guangdun Peng, Chinese Academy of Sciences, Guangzhou, Guangdong, China; ...

1 State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China 2 Haihe Laboratory of Modern Chinese Medicine, Tianjin University of ...

They both activate Mmp2, which is specifically expressed in the posterior FCs of stage 14 egg chambers and required for ovulation (11, 13, 14). In addition, ovulin, a male seminal protein, is ...