Mitosis orchestrates eukaryotic cell division, maintaining genetic fidelity and playing a key role in development, tissue homeostasis, and cancer progression.

Here we explore peptide inhibitors of Cdc20, a substrate-recognition subunit and activator of the E3 ubiquitin ligase the anaphase promoting complex/cyclosome (APC/C) that is essential in mitosis and ...

Cdk activity drives cell-cycle progression as far as metaphase, but progression into anaphase and beyond depends on another major regulatory component — a ubiquitin-protein ligase called the ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Cancer cells often display centrosome ...

Representative video frames showing (left to right) mitotic spindle at metaphase, early anaphase, late anaphase and telophase. The top row shows combined tubulin (green) and chromatin (magenta) ...