On May 13, at the ASGCT Annual Meeting, they will discuss their investigational gene therapy OPGx-MERTK, which aims to treat MERTK-related retinitis pigmentosa, showcasing promising preclinical ...

Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, 35, Keyan Road, Miaoli County, Zhunan Town 350, Taiwan, R.O.C. Institute of Biotechnology and ...

2189+1G>T in the tyrosine kinase receptor gene MERTK. Methods: Five affected children of a consanguineous Moroccan family were investigated by ophthalmic examinations, including fundus photography, ...

This review provides a brief overview of the surface markers expressed by EIMs, including α5-integrin, CD11b, CD16, CD163, CD169, CD206, CSF1R, EPOR, F4/80, Gr1, MerTK, PPARγ, Timd4, and VCAM1. We ...

OPGx-MERTK, an AAV vector for the treatment of MERTK IRD; OPGx-NMNAT1, a gene augmentation therapy designed to halt functional deterioration in pediatric patients with retinal degenerative disease ...

41 42 Recent studies have also shown that patients with ACLF have increased numbers of immunoregulatory monocytes and macrophages that express MER receptor tyrosine kinase (MERTK)and elevated plasma ...

Figure 3. Pruning effect of astrocytes on synaptic morphology. Astrocyte surface receptors MEGF10 and MerTK recognize phosphatidylserine in the target fragment as an opsonic signal, which induces ...

Macrophages play a central role in the development of atherosclerotic cardiovascular disease (ASCVD), which encompasses coronary artery disease, peripheral artery disease, cerebrovascular disease, and ...

Edited by Janet R. Sparrow, Columbia University, New York, NY, and accepted by Editorial Board Member Jeremy Nathans October 13, 2018 (received for review February 9, 2018) To estimate the relative ...

The heart is a never-stopping engine that relies on a formidable pool of mitochondria to generate energy and propel pumping. Because dying cardiomyocytes cannot be replaced, this high metabolic rate ...