This process is controlled by MAP4K4/6/7 kinases, which trigger ubiquitin phosphorylation. Then, phosphorylated ubiquitin induces H2AX recruitment to DNA damage sites, thereby activating DNA repair ...

Paradoxically, these same exosomes demonstrate protective effects through MAP4K4 and Gprc5a signaling pathways, potentially serving as endogenous modulators of intestinal IRI severity. These findings ...

⊥ Department of Chemistry, WuXi AppTec Co., Ltd., 288 Fute Zhonglu, Wai Gao Qiao Free Trade Zone, Shanghai, 200131, P. R. China *J.W.L.: phone, 650-467-2877; e-mail ...

Combined, these findings show that CMA displays a broad targetability on multiple steps of the EMT process and indicate a substantial role of CMA in regulating the stability of pro-metastatic and ...