Background: Regulated cell death (RCD) is a genetically controlled form of cell death that plays an important role in organogenesis, tissue remodeling, and pathogenesis of cancers. Transforming growth ...

During atherosclerosis, lipid-rich plaques are formed in large- and medium-sized arteries, which can reduce blood flow to tissues. This situation becomes particularly precarious when a plaque develops ...

In this context, miR-155 targets TGF-Beta Activated Kinase 1/MAP3K7 Binding Protein 2 (TAB2) resulting in decreased IFNα, while miR-155 * targets interleukin 1 receptor associated kinase 1 (IRAK1) ...

Combined, these findings show that CMA displays a broad targetability on multiple steps of the EMT process and indicate a substantial role of CMA in regulating the stability of pro-metastatic and ...