PIM protein kinases have been known for some time as oncogenes that promote lymphomagenesis together with MYC (c-Myc). It is now reported that PIM1 is a coactivator of MYC, and it phosphorylates ...

Figure 1: PML is required for Ras-induced senescence in primary cells. Figure 5: Colocalization of PML, CBP and p53 after expression of PML or RasV12. Infection of MEFs was carried out as described 1.

Background Current treatments with tyrosine kinase inhibitors and immune checkpoint inhibitors have limited efficacy for ...

Elephants seem to have 20 different copies of a tumor-suppressing gene known as p53. This gene encodes a protein, also known as p53, which serves as a crucial cell protector. This protein acts a ...

Domain organization of p53 isoforms. Overview of the so far described p53 isoforms that are formed by a combination of four N-terminal (TAp53, Δ40p53, Δ133p53 and Δ160p53) and three C-terminal ...