Targeting CDK7 Enhances the Antitumor Efficacy of Enzalutamide in Androgen Receptor–Positive Triple ... Downstream target analysis revealed that the enzalutamide and KRLS-017 combination dramatically ...

The presence of MYC translocation and high MYC mRNA expression have recently been associated with poor OS in patients with DLBCL treated with R-CHOP, raising questions about optimal management of ...

PIM protein kinases have been known for some time as oncogenes that promote lymphomagenesis together with MYC (c-Myc). It is now reported that PIM1 is a coactivator of MYC, and it phosphorylates ...

Both MYC amplification and high MYC protein expression have been associated with survival in exploratory studies. 8,11,13,23,24 The absence of prognostic value of MYC amplification in this study might ...

1 hour, 5 minutes. Several mayors joined policy advocates to discuss the Republican tax and spending cuts bill at the U.S. Conference of Mayors' annual meeting in Tampa, Florida.

Add to MyC-SPAN; Add program to calendar; Notify me when this airs ; Sign in to your MyC-SPAN account for airing and availability notifications. 11:00am U.S. House of Representatives: 06/20/2025.

The UK firm's lead project is CDK7-targeted GTAEXS617, currently in the phase 1/2 ELUCIDATE trial in advanced solid tumours, while Recursion has four candidates in phase 2 trials including REC-994 ...

Exscientia’s current clinical-stage pipeline consists of CDK7 inhibitor GTAEXS-617, which is co-owned with GT Apeiron, Evotec-partnered A2A receptor antagonist EXS-21546, and BMS-partnered PKC ...

Cooke EW, Zeng C, Nur SM, Jia Y, Huang A, Chen J, Gao P, Chen FX, Jin F, Cao K "H3K79 methylation and H3K36 tri-methylation synergistically regulate gene expression in pluripotent stem cells" bioRxiv.

WD repeat domain 5 (WDR5) is a member of the WD40-repeat protein family that plays a critical role in multiple processes. It is also a prominent target for pharmacological inhibition in diseases such ...