It affects approximately 100,000 children and adults in the US. The MEK1 and MEK2 inhibitor showed that it was able to reduce NF1-PN lesions in the 114-patient phase 2b ReNeu trial, with an ...

Coming after Ogsiveo at SprongWorks is Gomekli (mirdametinib), an oral small molecule designed to inhibit MEK1 and MEK2 proteins, which has been submitted for FDA approval as a treatment for ...

Communicated by Kevan M. Shokat, University of California, San Francisco, CA, June 28, 2010 (received for review April 16, 2010) PLX4032 Inhibits MEK and ERK Phosphorylation Only in Tumors with BRAF ...

Cardiac metabolic dysfunction is a hallmark of heart failure (HF). Estrogen-related receptors ERRα and ERRγ are essential regulators of cardiac metabolism. Therefore, activation of ERR could be a ...

Cover: The HIV protease inhibitor Nelfinavir promotes the activation of the kinase eEF2K. This triggers the phosphorylation of the translation factor eEF2 thereby reducing the rates of protein ...

Although IQGAP3 was established as a proliferating stomach stem cell factor and a regulator of the RAS-ERK pathway, how it drives cancer growth remains unclear. Objective We define the function of ...

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Georgia Southern University has introduced its 2025–26 Erk Russell Fund (ERF) membership license plate, paying tribute to the school's longtime mascot, “Freedom,” and recognizing his enduring impact ...