Background: Alrizomadlin, an investigational MDM2 inhibitor, has shown a manageable safety profile with preliminary efficacy in liposarcoma (LPS) and ACC and in combination with a PD-1/PD-L1 inhibitor ...

MANHATTAN, Kan. (WIBW) - The Kansas Department of Agriculture (KDA) is now accepting applications for a second round of grants under the Resilient Food Systems Infrastructure program.. According ...

We investigated clinicopathological features in paired specimens focusing on tumor-associated surface proteins potentially related to novel drug development such as MET, TROP2, HER2, B7-H4, and MDM2.

This year, two studies of the Bcl-2 inhibitor lisaftoclax (APG-2575) and the MDM2-p53 inhibitor alrizomadlin, key drug candidates in the company’s apoptosis-targeted pipeline, have been selected ...

ROCKVILLE, Md. and SUZHOU, China, June 02, 2025 (GLOBE NEWSWIRE) -- Ascentage Pharma (NASDAQ: AAPG; HKEX: 6855), a global biopharmaceutical company dedicated to addressing unmet medical needs in ...

Boehringer Ingelheim says it is on track to launch 25 new treatments in its human pharma division onto the market between now and 2030, fuelled by an R&D pipeline that it says is the best in its ...

Because p53 exists in cells as a homotetramer with a native mass of ≈212 kDa, MDM2 displays a molecular mass of ≈90 kDa on a SDS gel, and p300 is a ≈400-kDa polypeptide, we conclude that the purified ...

Mdm2 exhibits a dual relationship with p53 (reviewed in refs. 10–12). On the one hand, Mdm2 binding to p53 can repress the transcriptional functions of p53 and also lead to complete elimination of p53 ...

Caldwell County FFA member Evan Cotton is proudly wearing a new belt buckle to highlight his accomplishments during his swine showing career. Cotton says he was proud to earn the buckle Saturday at ...