Signalling also requires the MAPKKK Tak1 and its partner TAB2, which are needed for activation of both the NF-κB and the JNK MAPK branches. Activated TAK1 is thought to act on the IKK signalosome ...

Animal cells respond to differentiation signals which turn on or off the appropriate genes, resulting in the conversion of proliferating, undifferentiated cells into nonproliferating, highly ...

Redox signaling refers to the specific and usually reversible oxidation/reduction modification of molecules involved in cellular signaling pathways. In the heart, redox signaling regulates several ...

Zhejiang Key Laboratory of Smart Biomaterials, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310058, China Institute of Bioengineering, College of Chemical and ...

Communicated by Kevan M. Shokat, University of California, San Francisco, CA, June 28, 2010 (received for review April 16, 2010) PLX4032 Inhibits MEK and ERK Phosphorylation Only in Tumors with BRAF ...

Root and tuber crops (RTCs), which include cassava, potato, sweet potato, and yams, principally function as staple crops for a considerable fraction of the world population, in addition to their ...

Section of Digestive Diseases and Nutrition, University of Illinois at Chicago and Chicago Veterans Administration Medical Center (West Side Division), Chicago, IL, USA Correspondence to: Dr G Hecht, ...

Neurons are critically dependent on mitochondrial integrity based on specific morphological, biochemical, and physiological features. They are characterized by high rates of metabolic activity and ...

Facultad de Ciencias Ambientales y Bioquímica, Universidad de Castilla-la Mancha, Toledo, Spain For Differential Interference Contrast (DIC), cotyledons were fixed in ethanol:acetic acid 9:1 (v/v) for ...

Department of Microbiology and Parasitology, Faculty of Pharmacy, Complutense University of Madrid (UCM), 28040 Madrid, Spain ...