Histone H3 is shown as loading control. C. ChIP‐qPCR showing Lef1, Tcf3, and Tcf4 recruitment to Prex1 and Nrp2 regulatory regions in NCH421k cells. D. Expression qPCR validation of deregulation of ...

Remarkably, CLL-B cells from different patients exhibit tremendous heterogeneity in their response to the knockdown of a single gene, LEF1. This functional heterogeneity defines three distinct patient ...

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Oncolytic virus VG161 in combination with camrelizumab as second-line therapy in patients with advanced primary hepatocellular carcinoma: A phase Ib/IIa clinical study. This is an ASCO Meeting ...

From recent research on trauma to advances in genetics, here are 5 new developments in the world of bipolar disorder.

Faculty of Chemistry and Chemical Biology, Technical University Dortmund, Otto-Hahn-Strasse 6, 44227 Dortmund, Germany Compound Management and Screening Center, Otto-Hahn-Strasse 11, 44227 Dortmund, ...

Dysregulated Wnt signaling is a well-established driver of colorectal carcinogenesis. However, its pivotal role in normal intestinal stem cell homeostasis has posed significant challenges for its ...

This contribution is part of the special series of Inaugural Articles by members of the National Academy of Sciences elected in 2013. Reactivation is a key process that updates memory by strengthening ...

In this valuable study, the authors demonstrate that TCF7L2 plays a role in the pathogenesis of cachexia in a mouse model of GI cancer. The results are solid, although future studies will need further ...

This fundamental article significantly advances our understanding of FGF signalling, and in particular highlights the complex modifications affecting this pathway. The evidence for the authors' claims ...