The LKB1 tumour suppressor is a serine/threonine kinase that functions as master regulator of cell growth, metabolism, survival and polarity. LKB1 is frequently mutated in human cancers and ...

Figure 2.LKB1 controls ILC3 postnatal development. (A) Representative flow cytometric plots showing frequency of ILC3s in large intestine (LI) from Stk11 f/f and Stk11 ΔRorc mice at the indicated time ...

E3 ubiquitin ligases, which bind protein targets, leading to their ubiquitination and subsequent degradation, are attractive drug targets due to their exquisite substrate specificity. However, the ...

Estradiol (E2), the most potent form of estrogen, holds a central position in regulating physiological functions and influencing disease states across the female lifecycle. Carboxylesterases (CEs), as ...

Cancer genomic studies have identified frequent alterations in genes encoding components of the SWI/SNF chromatin remodeling complex, including SMARCA4 and ARID1A.Importantly, clinical reports ...

It has been reported that SIK3 is regulated by LKB1 (liver kinase B1: serine/threonine kinase 11)-mediated phosphorylation of T221, which activates the T-loop within the kinase domain .