Elephants seem to have 20 different copies of a tumor-suppressing gene known as p53. This gene encodes a protein, also known as p53, which serves as a crucial cell protector. This protein acts a ...

The major off- targeting effect is mediated through p53 activation, as detected through the transferase- mediated dUTP nick end labeling assay, acridine orange, and p21 transcriptional activation ...

Brdar, Osterburg, Munick, et al. present an interesting cellular and biochemical investigation of different p53 isoforms. The authors investigate the impact of different isoforms on the in-vivo ...

To attenuate physiological hypertrophy, Atrogin/MAFbx activates the activity of FOXO transcription factors through mediating the ubiquitination of K63 linked chains. Atrogin/MAFbx also inhibits ...

Ubiquitin is mainly connected in eight ways (M1, K6, K11, K27, K29, K33, K48, and K63), and can regulate different functions of substrate proteins. For example, K48 polyubiquitination mainly plays the ...

1Department of Genetics, The University of Texas MD Anderson Cancer Center, Houston, Texas. *Corresponding Author: Guillermina Lozano, Department of Genetics, The University of Texas MD Anderson ...