In this study, Karin and colleagues unveil two new mechanisms of action for JUN N-terminal kinase 1 (JNK1) in promoting obesity-induced insulin resistance. They show that JNK1 expression in non ...

§ Department of Internal Medicine, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy *Department of Chemical Sciences and Technologies, University of “Tor Vergata”, Via della ...

The heart utilizes large amounts of fatty acids as energy providing substrates. The physiological balance of lipid uptake and oxidation prevents accumulation of excess lipids. Several processes that ...

Smooth muscle cell migration occurs during vascular development, in response to vascular injury, and during atherogenesis. Many proximal signals and signal transduction pathways activated during ...

In the present study, we found that NaB inhibits FGF2 expression both in vivo and in vitro, subsequently suppressing FGF2/p38/runt-related protein 2 (RUNX2) signaling transduction, thereby inhibiting ...