Ivashkiv and colleagues show that IL-10 inhibits the expression and DNA binding of IRF1 and IRF5, two transcription factors that have an amplifying role in the induction of inflammatory NF-κB ...

Ivashkiv and colleagues show that IL-10 inhibits the expression and DNA binding of IRF1 and IRF5, two transcription factors that have an amplifying role in the induction of inflammatory NF-κB ...

The primary antibodies used for immunoblotting were anti-IL1β mouse monoclonal (Cell Signaling Technology, 12242), anti-IL6 rabbit monoclonal (Cell Signaling Technology, 12153), anti-IRF1 rabbit ...

Three machine learning algorithmssupport vector machine recursive feature elimination (SVM-RFE), least absolute shrinkage and selection operator regression (LASSO), and random forest (RF)-identified ...

Priming is mediated by pathways and mechanisms used in inflammatory signaling, including a stable STAT1 and IRF1 occupancy and histone acetylation. This priming process also makes cells more ...

Clinical outcomes and characterization of HER2 alterations in non-small cell lung cancer (NSCLC). This is an ASCO Meeting Abstract from the 2025 ASCO Annual Meeting I. This abstract does not include a ...

Chronic kidney disease (CKD) represents a global health issue with a high socioeconomic impact. Beyond a progressive decline of kidney function, patients with CKD are at increased risk of ...

Among various pathogens, viruses pose significant threats to the livestock and poultry industry, resulting in substantial annual costs due to production losses and vaccination. The MHC-I presentation ...

† School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China ‡ Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou 510080, China Article Views are the ...

The newly generated CD4 single-positive (SP) T lymphocytes are featured by enhanced IL-4 but repressed IFN-γ production. The mechanisms underlying this functional bias remain elusive. Previous studies ...