Type-1 interferons regulate immune responses and the production of self-reactive antibodies that target red blood cells in a SCD mouse model.

This study provides evidence that single-cell multi-omics profiling can reveal key regulators of HIV-1 persistence and early immune dysregulation, particularly implicating KLF2 and Th17 cells as major ...

Vitamin C is widely recognized for its immune-boosting properties, helping the body combat infections, reduce inflammation, and support the function of white blood cells.

Some asthmatics have impaired interferon (IFN) responses to RV, but the underlying mechanisms of this clinically relevant observation are poorly understood. Objectives To investigate the importance of ...

The liver performs hundreds of vital functions, including converting nutrients from food into energy, filtering toxins from the blood, and producing bile, a key substance in digestion and waste ...

Interferon beta injectable drugs were the first DMTs approved for MS treatment. The injections help change the course of active relapsing-remitting MS and secondary progressive MS. If a person has ...

Figure 1 Schematic overview of the direct and indirect effects of type III interferons on leukocyte phenotypes and functions. helper T cell (Th), T-box transcription factor (Tbet), interleukin (IL), ...

C57BL/6 mice deficient in interleukin12 or gamma interferon showed faster acute vascular rejection than did wild-type mice. Furthermore, mice defective in B-cell development showed no acute ...

We identify that in JDM CD14+monocytes, the pathogenic interferon (IFN) type 1 signature is associated with dysregulation of mitochondrial-associated gene expression. Assessment of mitochondrial ...

Type I interferons (IFNs) play a role in murine PBC; however, little is known regarding their involvement and the role of type II/III IFNs in PBC patients. The aim of this investigation was to explore ...

1Department of Pathology, Yale University, New Haven, Connecticut. Search for other works by this author on: 1Department of Pathology, Yale University, New Haven, Connecticut. 2Department of ...

This therapy employs systemic administration of the tissue hormone interferon-I combined with local application of Imiquimod. This combination showed promising results in topically accessible ...