Clinical Remission rate observed in all-comers population and sub-population according to composite IL7R axis biomarker in ...

ABS therapies target a branch of the interleukin-7 (IL7)-/interleukin-7 receptor (IL7R) pathway controlled by sIL7R, a critical amplifier of autoimmune reactions. As many as half of patients with ...

Comparison of sequential intravesical gemcitabine and docetaxel versus bacillus Calmette-Guérin in the treatment of non-muscle invasive bladder cancer: A meta-analysis. A first-in-human trial of ...

Adipose tissue (AT) is an endocrine organ with a central role on whole-body energy metabolism and development of metabolic diseases. Single-cell and single-nuclei RNA sequencing (scRNA-seq and ...

Introduction: Natural killer (NK) cells in mice and humans are key effectors of the innate immune system with complex immunoregulatory functions, and diverse subsets have been identified with distinct ...

Janus cells express Aire, RORγt and the integrin b8 (Itgb8) but lack ILC3 markers CXCR6 and IL7R. They phenotypically and transcriptionally resemble CCR7 + migratory cDCs (29, 35) and have primarily ...

The pattern of IFN gene expression is quite different in TP53 mutant Kasumi-1 cells, as DNMTi treatment alone drives pronounced increases in expression of 7/24 IFN genes (ID2, IFI27, IFI44, IL7R, IRF9 ...