Targeted deletion of integrin-associated protein CD47 enhances long-term engraftment of human CD34 + cells in immunodeficient pigs lacking IL2RG and RAG2, enabling large-scale production of ...

Genetic test was performed in 4/11 patients (36 %) by new-generation sequencing. Nonsense variants were found in the genes IL7RA, JAK3, IL2RG, and RAG1. Segregation analysis was not accomplished.

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. TP53 mutations in AML confer resistance to CAR ...

Atherosclerotic cardiovascular disease is a major cause of death among humans. Animal models have shown that cholesterol and inflammation are causatively involved in the disease process.

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Hormone therapy resistance and the ensuing ...

This study presents a valuable finding and developed ME3BP-7 as a novel microencapsulated formulation of 3BP, which specifically targets MCT1-overexpressing PDAC cells. It demonstrates its specificity ...

In recent years, protein arginine methyltransferases (PRMTs) have emerged as new members of a gene expression regulator family in eukaryotes, and are associated with cancer pathogenesis and ...

1Department of Gastric Surgery, Fujian Medical University Union Hospital, Fuzhou, China. 2Key Laboratory of Ministry of Education of Gastrointestinal Cancer, Fujian Medical University, Fuzhou, China.

Introduction: Distant metastasis (DM) is the most important prognostic factor affecting the overall survival (OS) of thyroid cancer. The current study aimed to discover prognostic biomarkers to ...

Knock-in of human SIRPA and IL15 in Rag2 −/− Il2rg −/− (RG) mice. (A) Schematic representation of the targeted mouse Sirpa allele with human exons 2 to 4 highlighted in blue.The encoded chimeric ...