Here the authors show that IL17A-producing NKp44- group 3 innate lymphoid cells accumulate in FAP duodenal tissue and are associated with duodenal adenoma formation in patients with FAP.

Introduction: Food allergies, like cow’s milk allergy, significantly impact children, with sensitization often beginning during the first year of life. Human milk oligosaccharides (HMOs) may influence ...

Additionally, a diverse array of chemokine family genes (IL2, IL4, IL17A, CCR2, CCL22) showed enhanced expression in PR group (Figure 3B). Furthermore, immune cell abundance analysis based on 11 ...

Employing novel pan-cancer targets for immunotherapy in leukemias and solid tumors. This is an ASCO Meeting Abstract from the 2025 ASCO Annual Meeting I. This abstract does not include a full text ...

Cancer immunotherapies have achieved unprecedented success in clinic, but they remain largely ineffective in some major types of cancer, such as colorectal cancer with microsatellite stability (MSS ...

1 Department of Medical Oncology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, China 2 Department of Breast Surgery, The First Affiliated Hospital of Xi’an Jiaotong University, ...

This study focuses on the role of a T-cell-specific receptor, ctla-4, in a new zebrafish model of IBD-like phenotype. Although implicated in IBD diseases, the function of ctla-4 has been hard to study ...

aState Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou 510060, China bGuangdong Esophageal Cancer ...

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dDivision of Pediatric Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, NY, USA eJill Roberts Center for IBD, Division of Gastroenterology and Hepatology, Department of Medicine, ...

Novartis Pipeline Benefiting from our continued focus on innovation, Novartis has one of the industry’s most competitive pipelines. Many of these projects, which include new molecular entities as well ...