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NLS Pharmaceutics Ltd. (NASDAQ: NLSP), a Swiss clinical-stage biopharmaceutical company focused on developing innovative therapies for central nervous system (CNS) disorders, today issued a letter ...
NLS, 13-7 overall, advances to play top-seeded Morris/Chokio-Alberta, which beat the Wildcats 7-1 in Spicer on April 15, at 5 p.m. Thursday at Morris. The Bulldogs finish 14-7 overall.
SPICER — The New London-Spicer American Legion baseball team opened the season with a 14-0, five-inning victory over the Paynesville Plums on Thursday night at the Green Lake Diamonds.
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Background: Aberrant accumulation of dsDNA in tumour cells activates the cGAS-STING pathway, playing a crucial role in anti-tumour immunity. However, the role of the dsRNA sensor RIG-I-like ...
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Subjects and methods The study subjects were female Balb/c pristane-induced lupus mice model, 8–12 weeks of age, n=30, divided into two groups, nephritis (LN group) and non-nephritis (SLE group). The ...
We revealed a mechanism in which a viral protein promotes the direct RIPK3 activation leading to inflammatory necroptosis and pathogenesis. The nonstructural protein NSs of a pathogenic hemorrhagic ...
The IRF1 and IRF2 proteins contain positive-acting nuclear localization signals (NLS) located immediately C-terminal to the DNA-binding domain, involving amino acids ≈120–140 . The IRF3 protein has a ...
ZSA-215 enhanced STING signaling through promoting the phosphorylation of STING and interferon regulatory factor 3 (IRF3) and secretion of IFN-β. Notably, monotherapy of oral ZSA-215 achieved complete ...