Background: UCPVax is a therapeutic vaccine designed to stimulate CD4+ helper T cell responses against telomerase (TERT), a protein highly expressed in glioblastoma (GBM). Temozolomide (TMZ), a ...

Background: Aberrant accumulation of dsDNA in tumour cells activates the cGAS-STING pathway, playing a crucial role in anti-tumour immunity. However, the role of the dsRNA sensor RIG-I-like ...

Plasmodium vivax (P. vivax) can lead to severe hematological complications, including anemia and thrombocytopenia, which may require hospitalization. This prospective observational study investigated ...

Subjects and methods The study subjects were female Balb/c pristane-induced lupus mice model, 8–12 weeks of age, n=30, divided into two groups, nephritis (LN group) and non-nephritis (SLE group). The ...

We revealed a mechanism in which a viral protein promotes the direct RIPK3 activation leading to inflammatory necroptosis and pathogenesis. The nonstructural protein NSs of a pathogenic hemorrhagic ...