In amongst a clutch of discontinued phase 3 programmes in Roche's fourth-quarter results update was the news that it has stopped a study of AKT inhibitor ipatasertib as a treatment for first-line ...

Background: Aberrant accumulation of dsDNA in tumour cells activates the cGAS-STING pathway, playing a crucial role in anti-tumour immunity. However, the role of the dsRNA sensor RIG-I-like ...

Subjects and methods The study subjects were female Balb/c pristane-induced lupus mice model, 8–12 weeks of age, n=30, divided into two groups, nephritis (LN group) and non-nephritis (SLE group). The ...

We revealed a mechanism in which a viral protein promotes the direct RIPK3 activation leading to inflammatory necroptosis and pathogenesis. The nonstructural protein NSs of a pathogenic hemorrhagic ...

ZSA-215 enhanced STING signaling through promoting the phosphorylation of STING and interferon regulatory factor 3 (IRF3) and secretion of IFN-β. Notably, monotherapy of oral ZSA-215 achieved complete ...