Viruses can evade immune surveillance and maintain their replication by inhibiting the enzyme activity of cGAS and reducing the phosphorylation levels of STING, TBK1 and IRF3 and suppressing the ...

These adaptors interact via the TIR domain with TLRs and activate TRAF3 or TRAF6, important proteins for NF-kB and IRF3/7 activation. SARM1 interacts with TLR adaptor proteins through its TIR domain, ...

Evaluating the immune landscape in early onset colorectal cancer patients. This is an ASCO Meeting Abstract from the 2025 ASCO Annual Meeting I. This abstract does not include a full text component.

Notably, IRF3 displayed high gene expression across heterogeneous populations of the HS epidermis (SI Appendix, Fig. S7A). Subsequently, we investigated whether the inactivity of IRF3 could repress HS ...

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