It reveals that, while IL23A, IL12B and IL23R are expressed at a high level in lesional skin, their expression in the synovium is hugely heterogeneous. It demonstrates that, while patients with ...

The team further found that interferon-gamma (IFN-γ) primes the chromatin for key promoters and enhancers of inflammation—including TNF, IL6, IL12B—preparing the genes for transcription. The primed ...

Introduction: Proinflammatory cytokines drive inflammation in the gastrointestinal tract leading to inflammatory bowel diseases (IBD) classified as either ulcerative colitis or Crohn's disease.