The well-studied NF-κB signaling system is a key mediator of the inflammatory response. Large-scale sequencing studies in ...

Myeloid differentiation (MyD) primary response and growth arrest DNA damage (Gadd) genes comprise a set of overlapping genes, including known (IRF-1, EGR-1, Jun) and novel (MyD88, Gadd45α, MyD118 ...

Promyelocytic leukemia protein (PML) is a tumor suppressor possessing multiple modes of action, including induction of apoptosis. We unexpectedly find that PML promotes necroptosis in addition to ...

3.3 In silico characterization of identified mutations. Both variants were classified as VUS, and several in silico variant effect prediction tools indicated that both variants might be deleterious.

2019 IKKalpha Kinase Regulates the DNA Damage Response and Drives Chemo-resistance in Cancer Mol Cell 75:669–682 Google Scholar; 40. Arthur J.S. Ley S.C; 2013 Mitogen-activated protein kinases in ...

eLife Assessment. This study provides valuable findings that MK2 inhibitor CMPD1 can inhibit the growth, migration and invasion of breast cancer cells both in vitro and in vivo. The evidence ...