Functional validation included binding kinetics (ELISA, flow cytometry, and fluorescence co-localization analysis), in vitro cytotoxicity assays (luciferase-based killing), and in vivo efficacy ...

Figure 2. The different role of PDE4A in tumor EMT. The expression of PDE4A is upregulated in MHCC97H and Huh7 cell, and promote the EMT. PDE4A is degraded by starvation induced autophagy in HepG2 ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. The mitochondrial calcium uniporter channel ...

The role of ACVR2A is potentially of importance to both the biology of trophoblast cells and to the pathogenesis of preeclampsia. In this manuscript, the authors have taken a useful first step towards ...

This work was supported by Deutsche Krebshilfe (70115440) to D.K. and the European Research Council under the European Union’s Horizon 2020 research and innovation program (Grant Agreement No. GA ...

Service de l’air, du bruit et des rayonnements non ionisants (SABRA), Geneva Cantonal Office for the Environment, 1205 Geneva, Switzerland Chair of Ecological Systems Design, Institute of ...

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Because of the exquisite sensitivity of these cell lines to induction of ferroptosis, we were unable to generate stable CRISPR knockout clones for MALT1 in either Huh7 or SK-Hep1 cells. Given that ...