Swiss-led study using single-cell RNA sequencing finds early immune activation in fibroblasts may be a key trigger in the ...

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84394), with the focus on the admixed South African populations. Ancestry adjustment models detected a peak of SNPs in the class II HLA DPB1, distinct from the class II HLA DQA1 loci signficant in the ...

The major genetic risk heterodimer, HLA-DQ2 and DQ8, is already used clinically to help exclude disease. However, approximately 40% of the population carry these alleles and the majority never develop ...

Among them is a dimeric NKG2A/CD94 inhibitory transmembrane (TM) receptor which specifically binds to the non-classical MHC I molecule HLA-E, which is often overexpressed on the surface of senescent ...

Since a linkage of the disease to the human leucocyte antigen (HLA) has not been shown, we here investigated whether MOGAD is associated with the HLA locus. Methods HLA genotypes of 95 patients with ...

Objective Human leucocyte antigen (HLA) B27 and HLA-B15 are associated with spondyloarthritis (SpA). Recent Assessment of SpondyloArthritis international Society (ASAS) criteria emphasise a ...

Furthermore, if the diagnostic criteria cited here are used together with HLA-A29 determination, early diagnosis before the pathognomonic BFLs are seen, becomes possible. It would therefore be ...

The accurate prediction of HLA-binding peptides is thus extremely useful for the mechanistic research of cell-mediated immunity and related epitope-based vaccine design. In this work, a simple ...

Proficiency testing (PT) has been part of Histocompatibility and Immunogenetics (H&I) since the early days. Starting from spontaneous interlaboratory comparisons, it gradually moved to more elaborate ...