Back in 2015, we identified a drug that may do just that, called harmine. This drug, which occurs naturally in a number of plants around the world, blocks an enzyme in the beta cells called DYRK1A.

During an analysis, they were able to identify three extremely potent beta-carboline alkaloids—harmine, harmaline, and tetrahydroharmine—by using high-performance liquid chromatography-tandem ...

Emerging evidence has indicated that harmine is an important endogenous compound, and its level is closely related to different physiological and disease states. Inspired by this, we propose a ...

Objective: To conduct a systematic literature review of animal and human studies reporting anxiolytic or antidepressive effects of ayahuasca or some of its isolated alkaloids (dimethyltryptamine, ...

DMT = N,N-dimethyltryptamine; HRM = harmine; HRL = harmaline; THH = tetrahydroharmine; (-) = not described in the study. The report on the articles was organized according to four therapeutic fields: ...

Ancient Saudi residents inhaled harmal smoke at home, revealing early psychoactive plant use and health practices.

Ovarian cancer(OC) is the second most common gynecological malignancy worldwide. While traditional treatments such as cytoreductive surgery, chemotherapy, and targeted drugs have made progress, ...

† Diseases of the Developing World, Tres Cantos Medicines Development Campus, GlaxoSmithKline, c/Severo Ochoa, 2, 28760, Tres Cantos, Madrid, Spain ‡ Robert Robinson Laboratories, Department of ...