Dr. Maarouf is a clinical scientist and analog astronaut. From simulating life on Mars at the Mars Desert Research Station to exploring healthcare technologies for astronauts, Dr. Maroouf shares how ...

Of the seven identified mammalian small HSPs, only αB-crystallin and HSP27 are stress-inducible and this regulation is believed to be controlled mainly by HSF transcription factors.

The Hsp27 protein can help cancer cells to protect themselves from cancer treatment. Hsp27 is only found in some types of lung cancer. The doctors in this trial think that by blocking Hsp27, or ...

HSP27 was also shifted to phosphorylated forms during pancreatitis. A lower dose of arginine (3.0 g/kg) induced less pancreatitis but a larger increase in HSP70 and HSP27 expression and ...

Under conditions of stress, Hsp27 has been shown to protect against protein misfolding and apoptosis. We have a long interest in the roles that heat shock proteins play in the survival of motor ...

Nintedanib (BIBF1120) is a potent, oral, small-molecule tyrosine kinase inhibitor, also known as a triple angiokinase inhibitor, inhibiting three major signaling pathways involved in angiogenesis.

We first confirmed that MK2i effectively inhibits MK2 activity in CAL-51 cells, as both 1 and 10 µM concentrations significantly reduced phosphorylation levels of Hsp27, a key downstream ...

In recent years, large-scale structure-based virtual screening has attracted increasing levels of interest for identification of novel compounds corresponding to potential drug targets. It is critical ...

Objective Pancreatic acinar cell maturation is dependent on the activity of the pancreas transcription factor 1 (PTF1) complex. Induction of pancreatitis leads to MAP kinase activation and transient ...