gut.bmj15d
Genome-wide association study identifies HLA-DR variants conferring risk of HBV-related acute-on-chronic liver failure
The roles of risk variants on clinical traits of ACLF were also analysed. Conclusions Our genome-wide association study identified HLA-DR as the major locus for susceptibility to HBV-related ACLF. Our ...
Frontiers2mon
Antigen–antibody complex density and antibody-induced HLA protein unfolding influence Fc-mediated antibody effector function
Donor-specific antibodies (DSAs) targeting mismatched human leukocyte antigen (HLA) molecules are one of the principal threats to long-term graft survival in solid organ transplantation. However, many ...
Frontiers11mon
Differences in F pocket impact on HLA I genetic associations with autoimmune diabetes
Introduction: Human leukocyte antigen (HLA) I molecules present antigenic peptides to activate CD8 + T cells. Type 1 Diabetes (T1D) is an auto-immune disease caused by aberrant activation of the CD8 + ...
Nature8y
HLA-DPB1 mismatch alleles represent powerful leukemia rejection antigens in CD4 T-cell immunotherapy after allogeneic stem-cell transplantation
We show herein that primary in vitro stimulation of CD45RA-selected CD4 T cells of stem-cell donors with 10/10 HLA-matched AML blasts results in expansion of cytolytic T-lymphocytes (CTL ...