Additionally, it has been noted that solid-phase technology can detect patient antibodies against denatured HLA molecules, as well as the native HLA molecules. In essence, the anti-HLA antibodies ...

The predominant problem underlying class distinction arises from the distribution of HLA antigens. MHC class I molecules are found on all nucleated cells, whereas MHC class II molecules are ...

Heart disease is the number one killer of men and women, but it often presents differently depending on sex. There are sex ...

Inhibition of nonsense-mediated decay turns immunologically cold tumors hot by increasing the amount of mutant RNA leading to an increase in T-cell-targetable neoantigens on the cell surface.

When scientists have used the artificial-intelligence tool called AlphaFold to predict the structure of dark proteins, the molecules often ... human leukocyte antigen (HLA) complex, which presents ...

These bars show that there is a significant increase in performance of the trans-allele method for HLA-DR molecules and decrease for HLA-DQ molecules compared with the intra-allele method. The ...

indicating key positions within HLA molecules that may confer risk. Differing associations in adult and juvenile onset disease with the same autoantibody suggests distinct aetiologies and disease ...

Figure 1. Expression of HLA-E in tumor cells and NKG2A in CD8 and NK cells. HLA-E molecules expressed on the tumor cells can inhibit activity of the CD8 and NK cells through NKG2A expressed on the CD8 ...

Altogether, this results in the release of damage-associated molecular pattern (DAMP) molecules and pathogen-associated molecular pattern (PAMP) molecules, both of which activate interferon-γ ...

Antigen processing and presentation is the mechanism by which whole antigens are degraded and loaded onto MHC molecules for display on the cell surface for recognition by T cells. Both macrophages ...

global biopharmaceutical company focused on developing differentiated molecules and combination therapies for people with cancer, today presented new data for casdatifan, a HIF-2a inhibitor with... at ...

The roles of risk variants on clinical traits of ACLF were also analysed. Conclusions Our genome-wide association study identified HLA-DR as the major locus for susceptibility to HBV-related ACLF. Our ...