A study shows that the histone deacetylases HDAC1 and HDAC2 stimulate oligodendrocyte differentiation by antagonizing the inhibitory action of Wnt signaling, linking genetic and epigenetic control ...

Unhealthy diets are a major impediment to achieving a healthier population in the United States. Although there is a relatively clear sense of what constitutes a healthy diet, most of the US ...

Molecular modeling and structure–activity relationships support binding to HDAC1 with tetrahydropyran acting as a hydrophobic shield from water at the enzyme surface. Such potent inhibitors of class I ...

In the present study, a series of novel histone deacetylase (HDAC) inhibitors using the morpholinopurine as the capping group were designed and synthesized. Several compounds demonstrated significant ...