Merck Sharp & Dohme LLC has identified compounds acting as potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (HCN1) and/or 2 (HCN2) blockers reported to be useful for the ...

Merck Sharp & Dohme LLC has identified compounds acting as potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (HCN1) and/or 2 (HCN2) blockers reported to be useful for the ...

Comparison of electrophysiological parameters of dopaminergic neurons in the SNc and VTA. HCN1 levels have been described to decrease dramatically in the temporal lobe of cynomolgus monkeys during ...

A comprehensive screen of 47 cyclic nucleotides with modifications in the nucleobase, ribose moiety, and cyclic phosphate was tested on the three isoforms HCN1, HCN2, and HCN4. 7-CH-cAMP was ...

The prefrontal cortex (PFC) provides 'top-down', higher-order guidance of thought, attention, behaviour and emotion, with dorsolateral regions regulating cognition, and ventromedial regions ...

Congratulations to the entire SiteOne family on acquisition by Eli Lilly announced this morning. It was an honor to serve as Exec Chair. Thanks to John Mulcahy, CEO, John Hunter, CSO, Diana Chung ...

Provided herein are novel pyrrolidinyl derivatives as HCN2 modulators, pharmaceutical compositions, use of such compounds in treating central nervous system (CNS) and psychiatric disorders, namely, ...