Metformin, a drug used as a first-line treatment for type 2 diabetes, has been associated with a 30% lower risk of death, ...

CDKN2A, VEGFA, SOX2, and FOXO3 were validated as key CS-DEGs, with high diagnostic potential for IPF. Functional enrichment analysis revealed their involvement in critical biological pathways, ...

Knockdown of miR-21-3p was shown to markedly inhibit F. nucleatum-mediated EMT and breast cancer cell migration. Additionally, predictions from online databases and cell model validations indicated ...

The mediating role of inflammation in the association between platinum-based chemotherapy and cardiovascular adverse events in older non-small cell lung cancer patients. This is an ASCO Meeting ...

Defective autophagy in macrophages leads to pathological processes that contribute to atherosclerosis, including impaired cholesterol metabolism and defective efferocytosis. Autophagy promotes the ...

In this valuable study, the authors demonstrate that TCF7L2 plays a role in the pathogenesis of cachexia in a mouse model of GI cancer. The results are solid, although future studies will need further ...

Edited by Pasko Rakic, Yale University, New Haven, CT, and approved September 23, 2016 (received for review June 6, 2016) ...