ECs exhibited abundant expression of multiple membrane receptors for ligands important for vascular development, including NOTCH1, NOTCH4, VEGF receptors (KDR, FLT1, FLT4, NRP1, NRP2), TGFβ receptors ...

Overall survival from the open label phase 2 trial of palbociclib in patients with advanced well differentiated/dedifferentiated liposarcoma. An update on the results ...

Follow-up data for KEYTRUDA ® (pembrolizumab) and WELIREG ® (belzutifan), as well as new and updated analyses for KEYTRUDA in earlier stages of cancer, add to the body of evidence supporting the ...

NUTLEY, N.J., May 20, 2025 /PRNewswire/ -- Eisai announced today the presentation of clinical research across its oncology portfolio and pipeline during the 2025 American Society of Clinical ...

Stress signalling is a cell signalling pathway that promotes a response to cell stress. Depending on the severity of the insult, stress signalling can mitigate the potential damage or induce ...

Immune checkpoint inhibitor (ICI) efficacy in triple-negative breast cancer (TNBC) patients with liver metastases (LM): A meta-analysis. This is an ASCO Meeting Abstract from the 2025 ASCO Annual ...

In nonsyndromic conotruncal cardiac defects, the use of next‐generation sequencing for clinical diagnosis is increasingly adopted, but gene‐disease associations in research are only partially ...

This manuscript focuses on developing a structural model of how the multidomain ECM protein SVEP1 enables Angiopoietin (ANG) binding to the orphan receptor TIE1, resulting in downstream receptor ...

Syndromes with lymphatic malformations show phenotypic variability within the same entity, clinical features that overlap between different conditions and allelic as well as locus heterogeneity. The ...

Correspondence to Professor Sahar Mansour, SW Thames Regional Genetics Service, St George's Hospital, London SW17 0RE, UK; smansour{at}sgul.ac.uk Primary lymphatic anomalies may present in a myriad of ...