FGFR2 gene fusion is observed in approximately 14% of intrahepatic cholangiocarcinoma, which accounts for 15%-30% of all biliary tract cancers, according to Eisai, but drug options are limited.

Eli Lilly has opened up a second market for its new Alzheimer's disease therapy Kisunla, after Japan followed the US in approving the drug.

Conditional ablation of Fgfr2 in the prostate epithelium compromises prostate development (Lin et al., 2007). Unlike the normal prostate that composed of 4 pairs of anterior, dorsal, lateral, and ...

Alongside, we will extract mouse fibroblasts from our FGFR2-C342Y mouse model and convert them into iPS cells. Similar to above, we can differentiate these into bone and/or cartilage and analyse their ...

In our lab we focus on the FGF receptors and study the effects of mutation of FGFR2 one of the receptor genes. Previous work has shown that FGFR2 is involved in the early pattering of the coronal ...

Learn about early diabetes symptoms, diabetic diet information, diabetes care, type 1 diabetes, insulin resistance and type 2 diabetes. Read the latest medical research on diabetes.

Nintedanib (BIBF1120) is a potent, oral, small-molecule tyrosine kinase inhibitor, also known as a triple angiokinase inhibitor, inhibiting three major signaling pathways involved in angiogenesis.

Browse the archive of articles on npj Precision Oncology. Case report: Successful use of MEK inhibitors as an adjuvant approach in the treatment of pediatric MAP4-RAF1 fusion-positive solid tumor ...