FANCM promotes activation of the Fanconi anemia pathway by coupling FANCD2 and FANCI monoubiquitination. Understanding FANCM’s dual roles opens new possibilities for cancer drugs that could target ...

RAD51C and XRCC3 are required for SSTR, but RAD51B and XRCC2 are not. They also found that FANCD2, a central player in the FA pathway, enriched even in the absence of an exogenous homology donor. In ...

Furthermore, the activation of the mTOR signaling pathway is associated with the upregulation of FANCD2, which may regulate sensitivity to platinum-based drugs by affecting the expression of DNA ...

Fanconi anemia is a rare inherited condition that can cause bone marrow failure, physical abnormalities, and an increased risk of some cancers. Symptoms include tiredness, infections, easy ...

Human exonuclease 1 (EXO1), a member of the structure-specific nuclease family, plays a critical role in maintaining genome stability by processing DNA double-strand breaks (DSBs), nicks, and ...

Lung cancer is by far the deadliest form of cancer and in many cases, there are no available therapeutic options for patients with this disease. Targeted therapies that inhibit oncogenic signaling and ...