The ERBB system consists of four receptors (ERBB1–4), two of which, ERBB2/HER2 and ERBB3 are non-autonomous. All four ERBB proteins form functional dimers after activation by epidermal growth ...

A recent study identifies aberrant ERBB3 low luminal progenitors with altered proteostasis and translation as the cell of origin of BRCA2-mutant breast cancer. Okreglak et al. explore the ...

There were 22 men with progressive mCRPC enrolled, the median age at enrollment was 66 years (range 52-80), the median PSA at original diagnosis was 82 ng/mL (range 5-3,648), 55% had a Gleason score 9 ...

Wuxi School of Medicine, Jiangnan University, Wuxi, Jiangsu, P.R. China Center for Neuroscience, Shantou University Medical College, Shantou, Guangdong, P.R. China ...

Molecular correlates of response in patients with metastatic castration-resistant prostate cancer treated with olaparib with or without cediranib (NCI9984). This is an ASCO Meeting Abstract from the ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Nuclear factor erythroid 2-related factor 2 ...

Advanced ovarian cancer (AOC) is prone to recurrence, which can be attributed to drug resistance. Drug resistance may be related to the tumor microenvironment (TME), including the immune and ...