Cymbalta (duloxetine) can cause a range of side effects when you stop taking it, especially if you discontinue it abruptly. This is known as a withdrawal or antidepressant discontinuation syndrome.

Purpose: The pharmacology, pharmacokinetics, efficacy, safety, drug interactions, dosage and administration, cost, and place in therapy of duloxetine for major depression, pain from diabetic ...

In this study, the safety and efficacy of duloxetine, a potent dual reuptake inhibitor of 5-HT and NE, were examined. Results: The rate of discontinuation due to adverse events was 11.3%.